| 线粒体与心肌细胞凋亡 |
| |
| 引用本文： | 王玮,高卫真. 线粒体与心肌细胞凋亡[J]. 医学综述, 2007, 13(20): 1541-1543 |
| |
| 作者姓名： | 王玮 高卫真 |
| |
| 作者单位： | 天津医科大学药理教研室,天津,300070 |
| |
| 摘 要： | 细胞凋亡又称程序化细胞死亡,是机体组织清除受损、衰老或多余细胞的一种自杀方式。研究表明,细胞凋亡在心脏发育及心力衰竭、原发性高血压、心律失常等许多心脏疾病的病理生理中起着重要作用。现知道,线粒体通过释放细胞色素C(Cyt C)和凋亡诱导因子(AIF)使细胞凋亡。这两种蛋白均能使体外分离的核凋亡。而AIF和Cyt C的释放均与线粒体膜电位及通透性的改变有关,且AIF的释放还受Bel-2基因产物的控制。
|
| 关 键 词： | 细胞凋亡 线粒体 心血管疾病 |
| 文章编号： | 1006-2084（2007）20-1541-03 |
| 收稿时间： | 2007-01-26 |
| 修稿时间： | 2007-08-16 |
Mitochondria and Myocardial Cell Apoptosis |
| |
| WANG Wei,GAO Wei-zhen. Mitochondria and Myocardial Cell Apoptosis[J]. Medical Recapitulate, 2007, 13(20): 1541-1543 |
| |
| Authors: | WANG Wei GAO Wei-zhen |
| |
| Affiliation: | Department of Phar- macology , Tianjin Medical University, Tianfin 300070, China |
| |
| Abstract: | Apoptosis is also called programmed cell death,which is a suicide method to get rid of impaired,senile or unnecessary cells.Researches showed that cell apoptosis played an important role in the pathophysiology of many heart diseases including heart development,heart failure,primary hypertension,arhythmia and so on.It is known that mitochondria can result in cell apoptosis by releasing cytochrome C and apoptosis inducing factors,which are both result in nuclear apoptosis in vitro.Further more,the releasing of AIF and Cyt C is related to the changes of membrane potential and permeability of mitochondria,among which the releasing of AIF is also controlled by gene products of Bel-2. |
| |
| Keywords: | Apoptosis Mitochondria Cardiovascular disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
