| 常见恶性肿瘤端粒酶活性检测 |
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| 引用本文： | 刘晓军,邹雅群,郭辰虹,陈丙玺,卢勇,龚瑶琴.常见恶性肿瘤端粒酶活性检测[J].中华肿瘤杂志,2001,23(1):25-27. |
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| 作者姓名： | 刘晓军 邹雅群 郭辰虹 陈丙玺 卢勇 龚瑶琴 |
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| 作者单位： | 山东医科大学医学遗传学教研室 |
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| 基金项目： | 山东省卫生厅“九五”攻关项目资助 |
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| 摘 要： | 目的 探讨端粒酶活性检测在常见恶性肿瘤诊断中的作用。方法 采用改良的银染端粒重复序列扩增方法，对283例恶性肿瘤、61例良性肿瘤和42例癌旁组织进行端粒酶活性检测。结果 283例恶性肿瘤中，264例检测到端粒酶活性，阳性率为93．3％；61例良性肿瘤中，4例检测到端粒酶活性，阳性率为6．6％；42例癌旁组织中，11例检查到端粒酶活性，阳性率为26．2％。结论 端粒酶的激活与恶性肿瘤的发生发展密切相关。端粒酶可以作为一种有效的恶性肿瘤标记物用于恶性肿瘤的诊断。
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| 关 键 词： | 端粒酶 恶性肿瘤 诊断 重复序列扩增 |
| 修稿时间： | 1999年12月24 |
Telomerase activity of common malignant tumors |
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| LIU Xiaojun,ZOU Yaqun,GUO Chenhong,et al..Telomerase activity of common malignant tumors[J].Chinese Journal of Oncology,2001,23(1):25-27. |
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| Authors: | LIU Xiaojun ZOU Yaqun GUO Chenhong |
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| Institution: | Department of Medical Genetics, Shandong Medical University, Jinan 250012, China. |
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| Abstract: | OBJECTIVE: To study the usefulness of detection of telomerase activity in the diagnosis of malignant tumors. METHODS: Modified telomeric repeat amplification protocol (TRAP) was employed to examine telomerase activity in 283 malignant tumor tissues, 42 adjacent tissues and 61 benign tumor tissues. RESULTS: Of the 283 malignant tumors and 42 adjacent tissues, telomerase was positive in 264 (93.3%) and 11 (26.1%), respectively. Only 4 of the 62 (6.6%) benign tumors were telomerase positive. CONCLUSION: Telomerase activity may be used as tumor marker in the diagnosis of malignant tumors. |
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| Keywords: | Neoplasms/diagnosis Telomerase/analysis |
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