| 心钠素基因G1837A多态性与出血性脑卒中的关系 |
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| 引用本文： | 张永利,杨期东,唐震宇,申向民,黄清,周琳. 心钠素基因G1837A多态性与出血性脑卒中的关系[J]. 卒中与神经疾病, 2007, 14(2): 76-78 |
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| 作者姓名： | 张永利 杨期东 唐震宇 申向民 黄清 周琳 |
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| 作者单位： | 410008,长沙,中南大学湘雅医院神经内科 |
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| 摘 要： | 目的 探讨心钠素（atrial natriuretic factor,ANF）G1837A基因多态性与出血性脑卒中的关系.方法 采用聚合酶链反应-限制型片断长度多态性（PCR-RFLP）的方法,分析104例出血性脑卒中患者和100例非脑血管病对照人群的（ANF）G1837A基因多态性分布.结果 总研究人群中ANF的G1837A的G和A 2种等位基因分布频率分别为86.3%和13.7% ANF的G1837A基因型和等位基因分布频率在2组人群中未发现显著性差异（P＞0.05）.结论 ANF的G1837A基因型与出血性脑卒中并无显著相关性,可能不是出血性脑卒中的遗传易感因素.
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| 关 键 词： | 心钠素 多态性 出血性脑卒中 |
| 文章编号： | 1007-0478（2007）02-0076-03 |
| 收稿时间： | 2006-09-27 |
| 修稿时间： | 2006-09-272006-12-18 |
The coroelation between G1837A polymorphism of ANF geng and the risk of hemorrhagic stroke |
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| Zhang Yongli, Yang Qidong, Tang Zhenyu,et al.. The coroelation between G1837A polymorphism of ANF geng and the risk of hemorrhagic stroke[J]. Stroke and Nervous Diseases, 2007, 14(2): 76-78 |
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| Authors: | Zhang Yongli Yang Qidong Tang Zhenyu et al. |
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| Affiliation: | Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008 |
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| Abstract: | Objective To investigate the potential association of atrial natriuretic factor (ANF) G1837A polymorphism and the risks of hemorrhagic stroke.Methods The genotypes of ANF G1837A was detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods in 104 consecutive hemorrhagic stroke patients (72 men and 32 women) and 100 controls (55 men and 45 women).Results The distributions of G alle and A alle of ANF G1837A polymorphism were 86.3% and 13.7% respectively. There was no difference of distribution of ANF G1837A polymorphism between hemorrhagic stroke group and control group (P>0.05).Conclusions Our results suggest that the (ANF) G1837A polymorphism may not be associated with hemorrhagic stroke and that (ANF) G1837A polymorphism is not a risk factor for hemorrhagic stroke. |
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| Keywords: | Atrial natriuretic factor Polymorphism Hemorrhagic stroke |
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