7,12-Dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract |
| |
| Authors: | S. ANDREJEVIC,J-F. SAVARY,C. FONTOLLIET,Ph. MONNIER,& H. VAN DEN BERGH |
| |
| Affiliation: | Department of Otolaryngology, Head and Neck Surgery —CHUV Hospital CH-1011 Lausanne;, Institute of Pathology, University of Lausanne, CH-1005 Lausanne;, Institute of Environmental Engineering, EPFL, CH-1005 Lausanne, Switzerland |
| |
| Abstract: | To test and optimize photodynamic therapy of early cancers in the upper aero-digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[ a ]anthracene-induced early squamous cell carinoma in the Golden Syrian hamster. This chemically induced neoplasm is shown, by histology and immunohistochemistry, to pass through similar stages of early cancer development as its human counterpart. Its time sequence is highly reproducible, leading to a well differentiated carcinoma in situ and microinvasive carcinoma in the hamster cheek pouch over a period of 10 weeks. |
| |
| Keywords: | 7,12-dimethylbenz[a]anthracene (DMBA) squamous cell carcinoma (SCC) photodynamic therapy (PDT) hamster cheek pouch mucosa |
|
|
