Analysis of the 1,4-benzodiazepines by methods based on hydrolysis |
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| Authors: | Gasparic J Zimák J |
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| Affiliation: | Department of Physical Chemistry, Faculty of Pharmacy, Charles University, 501 65 Hradec Králové, Czechoslovakia. |
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| Abstract: | The analytical applications of the hydrolysis of 1,4-benzodiazepines to the corresponding benzophenone derivatives are reviewed according to the analytical methods used for their final determination. The scope and limitations of the individual methods for the hydrolysis products are discussed: Colour reactions, photometry, fluorimetry, thin-layer chromatography, gas chromatography and high-performance liquid chromatography. Published data on the kinetic parameters and mechanisms are summarized in an attempt to explain the problems involved in exploiting this reaction for analytical applications. |
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| Keywords: | 1,4-Benzodiazepines 1,4-benzodiazepine hydrolysis TLC of benzophenone derivatives gas— liquid chromatography of benzophenone derivatives high-performance liquid chromatography of benzophenone derivatives fluorimetry of 1,4-benzodiazepines. |
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