Image-derived input functions for PET brain studies |
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Authors: | Jurgen E M Mourik Mark Lubberink Alie Schuitemaker Nelleke Tolboom Bart N M van Berckel Adriaan A Lammertsma Ronald Boellaard |
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Institution: | (1) Department of Nuclear Medicine and PET Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands;(2) Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands |
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Abstract: | Purpose To assess the robustness of a previously introduced method to obtain accurate image-derived input functions (IDIF) for three
other tracers.
Methods Dynamic PET and online blood data of five repeat 11C]PIB (Pittsburgh Compound-B) (11C]PIB), six repeat (R)-11C]verapamil, and ten single (R)-11C]PK11195 studies were used. IDIFs were extracted from partial volume corrected scans using the four hottest pixels per plane
method. Results obtained with IDIFs were compared with those using standard online measured arterial input functions (BSIF).
IDIFs were used both with and without calibration based on manual blood samples.
Results For (R)-11C]verapamil, accurate IDIFs were obtained using noncalibrated IDIFs (slope 0.96±0.17; R
2 0.92±0.07). However, calibration was necessary to obtain IDIFs comparable to the BSIF for both 11C]PIB (slope 1.04±0.05; R
2 1.00±0.01) and (R)-11C]PK11195 (slope 0.96±0.05; R
2 0.99±0.01). The need for calibration may be explained by the sticking property of both tracers, indicating that BSIF may
be affected by sticking and therefore may be unreliable.
Conclusion The present study shows that a previously proposed method to extract IDIFs is suitable for analysing 11C]PIB, (R)-11C]verapamil and (R)-11C]PK11195 studies, thereby obviating the need for online arterial sampling. |
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Keywords: | PET Image-derived input function Partial volume correction Sticking of [11C]PIB |
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