In Vivo Determination of ATP in Tumors Using 31P Inversion Spin Transfer |
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| Authors: | Luke J Haseler Brian T Bulliman Phillip W Kuchel David M Doddrell John R Bell Michael G Irving |
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| Institution: |
a School of Science, Griffith University, Nathan
b Department of Biochemistry, Sydney University, Sydney
c Department of Pathology, Mater Misericordiae Hospitals, South Brisbane, Australia |
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| Abstract: | The in vivo exchange kinetics of creatine kinase in the hind leg muscle of rats containing a transplanted mammary adenocarcinoma has been investigated using 31P magnetic resonance spectroscopy. Using a solenoid coil, the adenosine triphosphate (ATP) resonances arising from the tumor could be distinguished from ATP resonances arising from the muscle surrounding the tumor by use of inversion spin transfer techniques. This procedure affords a specific method of evaluating ATP metabolism of tumors in vivo. |
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