大鼠蛛网膜下腔出血后基底动脉病理结构的变化

目的观察大鼠蛛网膜下腔出血(SAH)后基底动脉病理结构的变化。方法采用枕大池二次注血的方法建立SAH大鼠模型,对照组同法注等量的生理盐水。观察两组大鼠基底动脉血管腔内周长、血管壁厚及其超微结构的改变。结果对照组大鼠基底动脉腔内周长、血管壁厚及其超微结构正常,SAH组大鼠血管腔内周长明显缩短,血管壁增厚,内皮细胞变性、内弹力膜增生变性、平滑肌细胞变性。结论大鼠SAH后脑血管痉挛的病理基础是血管内皮细胞通透性增高,内弹力膜增厚,平滑肌细胞变性。

Histopathological changes in basilar arteries of rats with subarachnoid hemorrhage

Objective To observe the histopathological changes in the basilar artery after subarachnoid hemorrhage（SAH）.Methods The model of SAH was established by twice injections of 0.3 ml autogenous arterial blood into the cistern magna in rats.Thei njection of 0.3 ml saline into the cistern magna was performed in control group.The luminal inner perimeter and wall thickness of the basilar arteries were measured and the ultrastructural change in the walls of the basilar arteries was observed in both the groups.Results The luminal inner perimeter of the basilar arteries were significantly shorter,and wall thickness was significantly thicker in SAH group than those in the control group（P0.01）3,5 and 7 days after SAH.The degenerations of endothelial cells internal elastic lamina which thickened and smooth muscle cells were observed in SAH group.The inner perimeter,wall thickness and wall ultrastructure of the basilar artery were normal in the control group.Conclusion The above-mentioned significant histopathological changes in the cerebral arteries produced by SAH in the rats is the basis of cerebral vasospasm after SAH.