| MMP-2在实验性大鼠慢性阻塞性肺疾病的表达及意义 |
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| 引用本文： | 王小莉,石莺,龚兴牡.MMP-2在实验性大鼠慢性阻塞性肺疾病的表达及意义[J].临床肺科杂志,2010,15(5):608-609. |
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| 作者姓名： | 王小莉 石莺 龚兴牡 |
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| 作者单位： | 吉首,湖南吉首大学医学院,湖南,416000 |
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| 基金项目： | 2006年湖南省卫生厅课题(B2006-135);;2008年吉首大学校级科研课题(08JDZC001) |
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| 摘 要： | 目的利用维A酸对实验性大鼠慢性阻塞性肺疾病(COPD)的干预,检测其MMP-2的变化并对其机制的探讨。方法Wistar雄性大鼠36只,随机分为三组:正常对照组、模型组和用药组,每组12只。模型组大鼠用药后观察各组大鼠肺组织的病理改变,免疫组化方法及酶联免疫试验观察肺组织MMP-2表达情况。结果模型MMP-2的活性和表达与正常对照组比较,差异有显著性(P0.01)。用药组MMP-2的活性和表达与模型组比较,差异有显著性(P0.01)。结论维A酸可降低COPD大鼠肺组织中MMP-2的表达,为COPD防治及治疗有很好的指导意义。
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| 关 键 词： | 维A酸 慢性阻塞性肺疾病 基质金属蛋白酶 |
Expression and significance of MMP-2 in experimental chronic obstructive pulmonary disease |
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| WANG Xiao-li,SHI Ying,GONG Xing-mu.Expression and significance of MMP-2 in experimental chronic obstructive pulmonary disease[J].Journal of Clinical Pulmonary Medicine,2010,15(5):608-609. |
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| Authors: | WANG Xiao-li SHI Ying GONG Xing-mu |
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| Institution: | WANG Xiao-li,SHI Ying,GONG Xing-mu.Medical College of Jishou Universtiy,Hunan Province 416000,China |
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| Abstract: | Objective To explore the change of the activity of matrixmetallop roteinase(MMP)-2 of lung tissue in the acute exacerbation of COPD rat models and the treatment effect of retinoic acid.Methods Thirty-six Wistar rats were randomly divided into three groups:the normal group,the model group(B)and the RA treated group(C),with 12 rats in every group.The rats in the group B were exposed to cigarette smoke,and the group C was treated with RA.Results The enzymatic activity and the expression of gelatinases were mar... |
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| Keywords: | retinoic acid chronic obstructive pulmonary diseases metalloproteinase |
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