| 用兔主动脉条研究小蘖碱和硝普钠对几种激动剂作用的影响 |
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| 引用本文： | 胡文淑,黄冬冬,方达超,江明性.用兔主动脉条研究小蘖碱和硝普钠对几种激动剂作用的影响[J].中国药理学通报,1988(2). |
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| 作者姓名： | 胡文淑 黄冬冬 方达超 江明性 |
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| 作者单位： | 同济医科大学药理教研室 武汉
(胡文淑，黄冬冬，方达超)，同济医科大学药理教研室 武汉(江明性) |
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| 摘 要： | 用离体家兔主动脉条观察Ber和NP的作用;NP降低血管条的基本张力,明显逆转由PE,HT、5-HT和KCl所引起的收缩,Ber仅逆转PE引起的收缩,对HT,5-HT和KCl引起的收缩无影响,也不影响血管条的基本张力。 Ber和Pra均阻断PE对血管条的收缩作用,两药的IC_(50)分别为30μM和0.2μM。 实验结果表明;NP非特异性逆转几种激动剂所致血管条的收缩,Ber仅逆转PE引起的血管收缩,其作用性质和Pra相似,提示Ber对血管条的α_1-肾上腺素受体具有选择性阻断作用。
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| 关 键 词： | 小蘖碱 硝普钠 哌唑嗪 苯肾上腺素 主动脉条 α-受体阻断作用 |
INFLUENCE OF BERBERINE AND SODIUM NITROPRUSSIDE ON THE ACTION OF SEVERAL AGONISTS IN THE AORTIC STRIPS OF RABBITS |
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| Hu Wenshu,Huang Dongdong,Fang Dachao & Jang Minxing.INFLUENCE OF BERBERINE AND SODIUM NITROPRUSSIDE ON THE ACTION OF SEVERAL AGONISTS IN THE AORTIC STRIPS OF RABBITS[J].Chinese Pharmacological Bulletin,1988(2). |
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| Authors: | Hu Wenshu Huang Dongdong Fang Dachao & Jang Minxing |
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| Abstract: | Berberine could reverse the phenylephrine-induced contraction of aortic strips of rabbits, but not those induced by histamine, serotonin and high-K. It showed no effect on the resting tension of the strips.
Prazosin l μM completely abolished the phenylephrine-induced contraction of the strips, but berberine 100 μM could block 94 ± 9%.
The IC50 of berberine and prazosin for phenylephrine-induced c-ontraction is 30 μM and 0.2 μM. The results suggest that the action of berberine is not similar to sodium nitroprusside, but is similar to prazosin, a selective α1 adrenoceptor blocker, although its potency is less than prazosin. |
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| Keywords: | Berberine Sodium nitroprusside Prazosin Phenylephrine Aortic strips α-adrenoceptor blocking action |
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