Recovery of response to adriamycin and cyclophosphamide by lonidamine in previously treated metastatic breast-cancer patients |
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| Authors: | Tomirotti M Bernardo G Epifani C Biasioli R Franchi R Mensi F Carnaghi P Schieppati G Scanni A |
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| Affiliation: | FDN CLIN LAVORO,PAVIA,ITALY. OSPED COMO,COMO,ITALY. OSPED MAGENTA,MAGENTA,ITALY. OSPED CODOGNO,CODOGNO,ITALY. OSPED MELEGNANO,MELEGNANO,ITALY. OSPED CASTELLANZA,CASTELLANZA,ITALY. OSPED SARONNO,SARONNO,ITALY. |
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| Abstract: | Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 partial remissions. Disease stability and progression were observed in 8 and 13 cases, respectively. These results were obtained with a marginal toxicity in addition to that already reported for AC therapy, the main additional side effect being myalgia, which was easily manageable in most cases. |
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