拉贝洛尔联合硫酸镁治疗妊娠高血压综合征的效果观察

目的：探讨拉贝洛尔联合硫酸镁治疗妊娠高血压综合征的临床效果。方法选取2011年7月~2013年6月本院收治的100例妊娠高血压综合征患者，将其随机分为观察组和对照组各50例。对照组采用硫酸镁进行治疗，观察组在对照组治疗的基础上加用拉贝洛尔进行治疗。比较两组治疗前后血压的改变、24 h尿蛋白量及分娩结局。结果治疗后两组收缩压及舒张压均明显下降，与治疗前比较，差异有统计学意义（P〈0.05），且观察组治疗后收缩压及舒张压的下降幅度明显大于对照组，差异有统计学意义（P〈0.05）。治疗后两组24 h尿蛋白量与治疗前比较，差异有统计学意义（P〈0.05），且观察组24 h尿蛋白量明显低于对照组，差异有统计学意义（P〈0.05）。观察组产后出血发生率明显低于对照组，差异有统计学意义（P〈0.05）；两组早产发生率、新生儿宫内窘迫发生率及新生儿出生体质量比较，差异无统计学意义（P〉0.05）。结论拉贝洛尔治疗妊娠高血压综合征效果确切，可平稳维持血压，较好缓解蛋白尿，减少产后并发症。

Effect observation of labetalol combined with magnesium sulfate in treat-ment of pregnancy induced hypertension syndrome

Objective To study the clinical effect of labetalol combined with magnesium sulfate in the treatment of pregnancy induced hypertension syndrome. Methods 100 patients with pregnancy induced hypertension syndrome treat-ed in our hospital from July 2011 to June 2013 were selected and randomly divided into the observation group and the control group,with 50 patients in each group.Magnesium sulfate was given to the control group,labetalol was added to the observation group on the basis of control group.The blood pressure changes,24-hour urine protein amount before and after treatment,delivery outcomes between the two groups were compared. Results The systolic pressure and dias-tolic pressure of both groups decreased significantly after treatment,compared with before treatment,the difference was significant （P〈0.05）;But after the treatment,the decreasing of systolic pressure and diastolic pressure in the observation group were more than those of the control group,with significant differences （P〈0.05）.The 24-hour urine protein of both groups decreased significantly after treatment,compared with before treatment,the difference was significant （P〈0.05）;Af-ter treatment,the urine protein amount of the observation group was lower than that of the control group （P〈0.05）.The incidence of postpartum hemorrhage in the observation group was lower than that of the control group,with significant difference （P〈0.05）.However,in terms of premature birth,neonatal intrauterine distress and neonatal birth weight,the two groups had no significant difference （P〉0.05）. Conclusion In the treatment of pregnancy induced hypertension syn-drome,labetalol shows accurate effects and can maintain blood pressure smoothly,relieve urine protein preferably and reduce postpartum complications.