早期输注大剂量氨基酸对早产儿营养状态的影响

目的：分析早期输注大剂量氨基酸对早产儿营养状态的影响。方法将本院收治的60例接受肠道外营养治疗的早产儿分为观察组（30例）和对照组（30例）。观察组行大剂量氨基酸静脉输注，对照组行小剂量氨基酸静脉输注，同时两组均在接受氨基酸肠外营养方案的基础上辅助行“全合一”静脉营养方案。于早产儿出生第14天，计算统计两组的相关生长发育指标和营养及代谢指标。结果出生后第14天，观察组早产儿体质量下降幅度小于对照组（P〈0.05），体质量增加速度、头围增加速度、身长增加速度均大于对照组（P〈0.05），且肠内营养能量达418.4 kJ/（kg·d）的天数、恢复出生体重天数均短于对照组（P〈0.05）。出生第14天，观察组早产儿平均血清前清蛋白（pre-Alb）水平高于对照组（P〈0.05），而两组的血清肌酐（Cr）、直接胆红素（DBiL）及钙指标水平比较，差异无统计学意义（P〉0.05）。结论早期输注大剂量氨基酸有助于改善早产儿的营养状况，促进早产儿生长，且对机体代谢影响小，安全性好。

The influence of large dose of amino acid early infusion on nutritional sta-tus in premature infants

Objective To analyze the influence of large dose of amino acid early infusion on nutritional status in prema-ture infants. Methods 60 premature infants admitted to our hospital for treatment of parenteral nutrition were divided into observation group （30 cases） and control group （30 cases）.Large dose of amino acid infusion was given to the obser-vation group,small dose of amino acid infusion was taken to the control group,at the same time,two groups of preterm infants were given with＂all in one＂intravenous nutrition scheme based on an amino acid parenteral nutrition solutions. In section 14 days,the growth and development indicators and indicators of nutrition and metabolism of two groups were calculationed and statisticsed. Results 14 days after birth,the premature infants body weight decreasing of observation group was less than that of the control group （P〈0.05）,increasing of body weight,head circumference,height velocity were higher than those in the control group （P〈0.05）,and the days of enteral nutrition energy up to 418.4 kJ/（kg·d）,the days of birth weight recovery were shorter than those of the control group （P〈0.05）.Born in 14 days,the mean pre-Alb levels of the observation group were higher than those of the control group （P〈0.05）,but the Cr,DBiL and calcium levels had no sig-nificant differences （P〉0.05）. Conclusion Large dose of amino acids early infusion can improve the nutritional status of premature infants,can promote the growth of premature infants,and the influence to metabolism is small,has good safety.