XIAP mRNA和Survivin mRNA在非小细胞肺癌的表达及其临床意义

 目的　检测非小细胞肺癌（NSCLC）中X连锁凋亡抑制蛋白（XIAP）mRNA和Survivin mRNA的表达，探讨其与患者临床病理因素的相关性。方法　收集59例NSCLC患者肿瘤和正常组织标本。采用RT-PCR检测XIAP mRNA和Survivin mRNA在肿瘤和正常组织中的表达。结果　XIAP mRNA在肿瘤组织的表达率高于正常组织，分别为61.0 %（36／59）和30.5 %（18／59）（P＜0.05），其表达与临床病理因素无相关性；Survivin mRNA在肿瘤的表达率高于正常组织，分别为81.4 %（48／59）和23.7 %（14／59）（P＜0.05），其表达与临床病理因素无相关性。结论　XIAP和Survivin可能在NSCLC发生、发展过程中有一定作用，有可能成为NSCLC诊断的标志物和治疗靶点。

Expression of XIAP mRNA and Survivin mRNA in non-small cell lung cancer and their clinical significance

Objective To investigate the clinical significance of the expression of XIAP mRNA and Survivin mRNA in non-small cell lung cancer and their relationship. Methods RT-PCR was used to evaluate the expression of XIAP mRNA and Survivin mRNA in 59 cases of NSCLC and corresponding normal tissues.Results There was a significant difference in XIAP mRNA expression in primary lung and corresponding normal tissues (61.0 % vs 30.5 %, P<0.05), whereas there were no significant correlation between the XIAP mRNA expression and gender, age, smoking history, histological subtype, T stage, lymph node metastatic status and TNM stage. There was a significant difference in Survivin mRNA expression in primary lung and corresponding normal tissues (81.4 % vs 23.7 %, P<0.05), whereas there were no significant correlation between the Survivin mRNA expression and gender, age, smoking history, histological subtype, T stage, lymph node metastatic status and TNM stage. Conclusion The significant difference of XIAP mRNA and Survivin mRNA expression between the tumor and corresponding normal tissues implies they might play important roles in the carcinogenesis and progress of NSCLC and might become marker for the diagnosis and target for treatment of NSCLC.