焦虑障碍患者血浆脑源性神经营养因子水平的研究

目的 探讨焦虑障碍患者血浆脑源性神经营养因子(BDNF)水平的特点.方法 收集广泛性焦虑症(GAD)患者104例,强迫症(OCD)患者114例,社交焦虑症(SAD)患者37例及63名正常对照者,其中GAD、OCD和SAD组内按入组时药物使用情况各分为两个亚组:A组为从未使用过任何精神科药物者或经过药物清洗1周及以上者;B组为入组时正在进行药物治疗者.采用汉密尔顿焦虑量表(HAMA)/耶鲁-布朗强迫量表(Y-BOCS)/交往焦虑量表(IAS)和状态-特质焦虑问卷(STAI)进行评分;采用ELISA法测定血浆BDNF的质量浓度;并对其中18例患者于药物治疗10周后复测各量表及血浆BDNF的质量浓度.结果 ①各病例组血浆BDNF质量浓度均低于正常对照组,差异有统计学意义(P<0.001),但病例组间两两比较差异无统计学意义(P>0.05).②各病例组内A、B亚组间血浆BDNF质量浓度差异均无统计学意义(P>0.05).③年龄、性别对各组血浆BDNF质量浓度均无统计学意义的影响(P>0.05);各病例组患者血浆BDNF质量浓度与疾病的严重程度、焦虑状态评分、病程的关联程度均无统计学意义(P>0.05).④18例患者经药物治疗10周后,血浆BDNF质量浓度变化无统计学意义(P>0.05).结论 血浆BDNF的水平可能为焦虑障碍疾病状态的生物学标志之一.

Analysis of plasma brain-derived neurotrophic factor levels in patients with anxiety disorders

Objective To explore the characteristics of plasma brain-derived neurotrophic factor(BDNF) levels in patients with anxiety disorders. Methods One hundred and four patients with generalized anxiety disorder(GAD),114 patients with obsessive-compulsive disorder(OCD),37 patients with social anxiety disorder(SAD) and 63 normal controls were enrolled,and patients in GAD,OCD and SAD groups were divided into two subgroups,respectively(subgroup A: those with no history of antipsychotic drug use or those with drug wa...