The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways |
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| Authors: | Favaro E Granata R Miceli I Baragli A Settanni F Cavallo Perin P Ghigo E Camussi G Zanone M M |
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| Institution: | (1) Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy;(2) Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, University of Turin, Turin, Italy; |
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| Abstract: | Aims/hypothesis Pancreatic islet microendothelium exhibits unique features in interdependent relationship with beta cells. Gastrointestinal
products of the ghrelin gene, acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin (Ob), and the incretin, glucagon-like
peptide-1 (GLP-1), prevent apoptosis of pancreatic beta cells. We investigated whether the ghrelin gene products and the GLP-1
receptor agonist exendin-4 (Ex-4) display survival effects in human pancreatic islet microendothelial cells (MECs) exposed
to chronic hyperglycaemia. |
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