Type-common and type-specific monoclonal antibodies to herpes simplex virus types 1 and 2. |
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Authors: | M Bystrická M Vancíková M Kasalová J Rajcáni M Kostál M Murányiová K Poláková G Russ |
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Affiliation: | Institute of Virology, Slovak Academy of Sciences, Bratislava. |
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Abstract: | Seventeen monoclonal antibodies (Mabs) reacting specifically with the cells infected with herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) were characterized by a variety of immunological tests such as radioimmunoprecipitation, immunoblotting and virus-neutralization. The majority of Mabs was directed against glycoprotein B (anti-gB), six reacted with glycoprotein C (anti-gC) and one with glycoprotein G (anti-gG). Six anti-gB Mabs reacted with both types of HSV (anti-gB-1,2), two anti-gB and all the six anti-gC Mabs have been specific for HSV-1 (anti-gB-1 and anti-gC-1). The remaining two anti-gB Mabs and the anti-gG have been specific to HSV-2 (anti-gB-2 and anti-gG). Only three out of the seventeen examined Mabs neutralized the virus. |
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