| RASSF2A Promoter Methylation in Hepatitis B Virus-related Hepatocellular Carcinogenesis and Its Correlation with Elevated Serum α-Fetoprotein Level |
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| 引用本文： | 任精华,何文山,张瑞光,李振宇,曹文淼,姚杰,朱芳,张涛,伍钢.RASSF2A Promoter Methylation in Hepatitis B Virus-related Hepatocellular Carcinogenesis and Its Correlation with Elevated Serum α-Fetoprotein Level[J].华中科技大学学报(医学英德文版),2009,29(3):309-312. |
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| 作者姓名： | 任精华 何文山 张瑞光 李振宇 曹文淼 姚杰 朱芳 张涛 伍钢 |
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| 作者单位： | Jinghua REN,Ruiguang ZHANG,Zhenyu LI,Wenmiao CAO,Jie YAO,Fang ZHU,Tao ZHANG,Gang WU(Department of Cancer Center, Union Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China);Wenshan HE(Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) |
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| 摘 要： | Loss of the RASSF2A expression induced by methylation-mediated silencing has been reported in several human cancers, but the methylation status of RASSF2A in hepatocellular carcinoma （HCC） is rarely studied so far. In this study, we investigated the RASSF2A expression and its methylation status in a cohort of 45 hepatitis B virus-associated HCC tissues and their adjacent non-carcinoma tissues by using RT-PCR and MS-PCR. Promoter methylation of RASSF2A was found in 31 （68.9%） out of 45 HCC tissues and 12 （40%） out of 30 adjacent normal tissues, respectively （P〈0.05）. The methylation status of PASSF2A was closely associated with the loss of RASSF2A expression and elevated serum α-fetoprotein level, but not significantly with clinical stage, hepatic fibrosis and K-ras mutation. It was concluded that aberrant methylation of the RASSF2A gene with the subsequent loss of RASSF2A expression plays an important role in the pathogenesis of HCC.
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| 关 键 词： | 肝细胞 肝肿瘤 治疗 HCC |
| 收稿时间： | 24 July 2009 |
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