基于关联规则等方法的十八反藜芦类反药配伍方剂特点分析

探讨“十八反”藜芦类反药配伍方剂年代、剂型和用药特点.从96 429张方剂中搜集到藜芦类方剂100首,采用关联规则、对应分析的方法分析药物配伍、年代和剂型之间的关联关系.藜芦类方剂在在配伍药物方面,与细辛、附子、雄黄、苦参、川芎、人参、肉桂、桔梗、干姜、当归等配伍较多.用法以外用散剂居多.藜芦类反药配伍方剂以宋代运用频率最高,剂型以外用散剂为主,该类方剂较为重视与温阳益气、燥湿化痰、行气活血等药物的配合运用.

Analysis on Characteristics of Formulas with Radix et Rhizoma Veratri Nigri Pairs of the 18 Forbidden Incompatible Drugs by Regulation Rules and other Mining Methods

To explore the characteristics of era,preparation and drugs of the formulas which contain the incompatible Radix et Rhizoma Veratri Nigri pairs of the ’18 forbidden incompatible drugs’.One hundred formulas containing Radix et Rhizoma Veratri Nigri pairs were selected out of 96 429 formulas;association rules and correspondence analysis were applied to the 100 formulas to investigate the above-mentioned features.The formulas containing Radix et Rhizoma Veratri Nigri pairs were usually combined with Radix et Rhizoma Asari,Radix Aconiti Lateralis Praeparata,Realgar,Radix Sophorae Flavescentis,Rhizoma Chuanxiong,Radix et Rhizoma Ginseng,etc;and powder was the most common preparation for external use.The formulas containing Radix et Rhizoma Veratri Nigri pairs were most frequently used in Song Dynasty in powder;they lay heavy emphasis on the combination with drugs for warming yang qi,drying dampness to resolve phlegm,and activating qi and blood circulation.