乌头类有毒中药配伍减毒增效的研究进展

总结近年来川乌、附子常用药对在临床应用、化学研究、药理毒理研究等方面所取得的进展,为临床安全有效应用乌头类中药提供理论依据.通过阅读大量近几年川乌、附子常用药对的文献报道,对其进行总结概述.川乌和附子通过合理配伍,可达到减毒增效的作用,扩大其应用范围.目前的川乌、附子配伍减毒研究已取得了一定进展,但研究还不够深入,需要进一步研究配伍减毒增效作用的机制,为临床应用提供科学依据.

Progress on Decreasing Toxicity and Increasing Efficacy Through Compatibility of Aconitine Root Species

To summarize the research process of universal herbal pair containing aconitine in recent years, including clinical application, chemical research, pharmacological and toxicological research, apply theoretical bases of the aconite root species safely and effectively used in clinical application. Literatures on universal herbal pair containing aconitine in recent years were summarized and analyzed. Suitable compatibility of Aconitine root species can decrease toxicity and increase efficacy, enlarge applied range. There are some advancements in studies on reducing the toxicity and increasing efficacy of aconitine by using compatibility at present, but many researches are superficial, so it is necessary for us to further study the mechanism of detoxification and synergism by using compatibility, in order to apply theoretical bases of clinical application.