| 威弛搽剂治疗家兔急性软组织损伤的实验研究 |
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| 引用本文： | 都兴东,刘军权,李德本. 威弛搽剂治疗家兔急性软组织损伤的实验研究[J]. 药学实践杂志, 2007, 25(1): 15-18 |
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| 作者姓名： | 都兴东 刘军权 李德本 |
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| 作者单位： | 中国人民解放军第97医院,江苏,徐州,221004 |
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| 基金项目： | 上海市-SK研究与发展基金 |
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| 摘 要： | 目的:研究糙叶败酱中环烯醚萜苷元成分体外抗小鼠结肠癌细胞株C26作用和对小鼠结肠癌(C26)移植性肿瘤的作用。方法:采用四唑盐(MTT)比色法研究糙叶败酱中环烯醚萜苷元PS-Ⅰ和BJ3401对小鼠结肠癌细胞株C26生长的影响;于F1小鼠皮下注射小鼠结肠癌细胞株(C26)建立小鼠结肠癌移植性肿瘤模型,观察糙叶败酱中总环烯醚萜苷元对结肠癌移植性肿瘤小鼠的影响。结果:环烯醚萜苷元PS-Ⅰ、BJ3401可显著抑制小鼠结肠癌细胞株C26的生长,并且具有一定的剂量依赖关系;总环烯醚萜苷元可显著减轻荷瘤鼠瘤重。结论:糙叶败酱中环烯醚萜苷元具有抗结肠癌的作用。
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| 关 键 词： | 糙叶败酱 抗肿瘤 环烯醚萜苷元 人结肠癌细胞株C26 |
| 文章编号： | 1006-0111(2007)01-0010-03 |
| 收稿时间： | 2006-05-29 |
| 修稿时间： | 2006-03-20 |
Experimental study of Weichi liniment on treating acute soft tissue injury |
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| DU Xing-dong,LIU Jun-quan and LI De-ben. Experimental study of Weichi liniment on treating acute soft tissue injury[J]. The Journal of Pharmaceutical Practice, 2007, 25(1): 15-18 |
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| Authors: | DU Xing-dong LIU Jun-quan LI De-ben |
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| Affiliation: | 1. Department of Pharmacy, No.85 Hospital of PLA, Shanghai 200052, China; 2. Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China; 3. Department of Phytochemistry, College of Pharmacy, Shanghai 200433, China |
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| Abstract: | Objective:To study the effects of the iridoid aglycones from Patrinia scabra on mouse colon cancer cell line C26 in vitro and on transplanting-tumor of mouse colon cancer cell C26.Methods:The effects of the iridoid aglycones from Patrinia scabra(PS-I, BJ3401)on mouse colon cancer cell line C26 were studied by MTF experiment,the transplanting-tumor model of mouse colon cancer was established by hypodermic inoculating the mouse colon cancer cell lines C26 into the FI mice.Results:The iridoid aglycones PS -I and BJ3401 could significantly inhibit proliferation of C26 cell line in a doge-dependent manner,gross iridoid aglycones could sig- nificantly lessen the weight of the transplanting-tumor in mice.Conclusion :The iridoid aglycones from Patrinia scabra have anti-colon carcinoma activity. |
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| Keywords: | Patrinia scabra the iridoid aglycones mouse colon cancer line C26 transplanting-tumor |
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