厦门地区献血者细小病毒B19抗体检测及流行病学分析

目的了解厦门地区献血者细小病毒B19感染情况,为输血保障工作提供依据。方法对部分厦门地区献血者标本进行细小病毒B19抗体检测,并对抗体阳性献血者进行流行病学分析;对其中部分细小病毒B19-Ig M阳性标本进行细小病毒DNA检测,分析细小病毒B19-Ig M阳性与病毒血症的关系。结果在1 078名献血者中,细小病毒B19-Ig M阳性率为4.7%(51/1 078),细小病毒B19-Ig G阳性率16.7%(181/1 078),总抗体阳性率20.3%(219/1 078);总抗体阳性率随年龄段增大而升高(χ2=7.948,P0.05),本省籍献血者阳性率低于外省籍(χ2=6.994,P0.05),不同职业献血者中农民的阳性率最高占35.47%,不同性别、血型的献血者阳性率差异无统计学意义;33份细小病毒B19-Ig M阳性标本仅检出2份细小病毒DNA阳性,献血者细小病毒B19核酸阳性率不低于0.18%(2/1 078)。结论厦门地区献血者中存在细小病毒感染,在今后的输血保障工作中应引起重视。

Detection and epidemiology analysis of parvovirus B19 in blood donors of Xiamen

Objective To estimate the prevalence of parvovirus B19 infection in blood donors of Xiamen and provideevidence for blood transfusion safety. Methods Blood samples from blood donors were tested for B19 IgG and IgM antibody.Epidemiological analysis was performed in B19 antibody positive donors. B19-IgM positive samples were tested for B19 DNAso as to evaluate the correlation between B19-IgM and occurence of viremia. Results Of 1 078 donations,51 samples wereB19-IgM positive（4.7% ）,181 were B19-lgG positive（16.7% ）,and overall seroprevalence was 20.3% （219/1 078）,whichincreased with age （X2=7.948 , P 〈0.05 ）. The lower positive rate were found in Fujian-native donors than in non Fujian-native（X2=6.994 , P 〈0.05）.And the highest positive rate were observed in farmers （35.47%）.No significant difference in positive rateamong different groups of gender or blood type were found. Of 33 parvovirus B19 positive samples, only 2 were positiveparvorirus DNA with the total positive rate of 0.18% （2/1 078）. Conclusions There was still a certain percentage ofparvovirus B19 infection in blood donors in Xiamen and attention be paid to blood transfusion safety in the future.