无精子症患者配偶行ICSI后妊娠结局影响因素分析

目的探讨影响无精子症患者配偶行ICSI后妊娠结局的相关因素。方法回顾性分析2009年1月~2013年10月共184例完成PESA-ICSI-ET治疗周期患者妊娠结局与影响因素,根据妊娠结局分为未妊娠组、单胎妊娠组及双胎妊娠组。结果 3组女方年龄分别为[(31.06±4.29)岁、(30.13±3.42)岁、(29.69±4.24)岁]、用Gn天数[(10.89±1.78)d、(10.96±1.98)d、(10.81±2.03)d]、Gn用量[(32.02±11.65)支、(30.15±13.99)支、(30.35±10.29)支]、HCG日子宫内膜厚度[(11.95±2.39)mm、(12.01±2.13)mm、(12.07±2.77)mm]、获卵数[(11.50±5.62)、(11.58±5.87)、(11.25±5.42)]相比差异无统计学意义(P0.05),男方的年龄未妊娠组(35.47±6.52)岁高于单胎妊娠组(33.01±5.41)岁和双胎妊娠组(33.13±5.99)岁,结果差异有统计学意义(P0.05),3组正常受精率(81.67%VS82.78%VS82.86%)、正常卵裂率(81.67%、82.78%、82.86%)相比差异无统计学意义(P0.05)。3组A级胚胎[(2.85±1.86)、(3.11±2.03)、(3.03±1.81)]、B级胚胎[(3.83±2.66)、(3.48±1.97)VS(3.52±2.02)]相比无显著差异(P0.05)(t检验)。结论随着男方无精子症患者年龄的增加,其配偶行ICSI治疗后的妊娠机会降低。

Analysis of influential factors on the pregnancy outcome in azoospermia patients spouse after ICSI

Objective To explore the factors related to pregnancy outcome in azoospermia patients spouse after ICSI.Methods Retrospective analysis of 2009 January to 2013 October of 184 PESA-ICSI-ET cycles,the pregnancy outcome is divided into a non pregnancy group,single pregnancy group and twin pregnancy group.Results There were no significant differences among the three groups in female age[（31.06±4.29） years old VS（30.13±3.42）years old VS（29.69±4.24）years old],Gn days[（10.89±1.78）daysVS（10.96±1.98）daysVS（10.81±2.03）days],Gn dose[（32.02±11.65）branchesVS（30.15±13.99）branchesVS（30.35±10.29）branches,emdometrial at hCG day[（11.95±2.39）mmVS（12.01±2.13）mmVS（12.07±2.77）mm],retrieved Oocytes[（11.50 ±5.62） VS（11.58±5.87） VS（11.25±5.42）]（P 0.05）.Male age in non pregnancy group showed a significantly higher（35.47±6.52 years old）then those of single pregnancy and twin pregnancy group[（33.01±5.41 years old）and（33.13 ±5.99 years old）]（P 0.05）.There were no significant differences among the three groups in Fertilization rate（81.67%VS82.78%VS82.86%）,cleavage rate（81.67%VS82.78%VS82.86%）（P0.05）.There were no significant differences among the three groups in A embryos[（2.85±1.86）VS（3.11±2.03）VS（3.03±1.81）],B embryos[（3.83±2.66）VS（3.48±1.97）VS（3.52± 2.02）]（P 0.05）.Conclusion Increasing male age is related with decreasing chance of pregnancy in azoospermia patients spouse after ICSI.