Upgrading from Single Chamber Right Ventricular to Biventricular Pacing in Permanently Paced Patients with Worsening Heart Failure: The RD-CHF Study |
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Authors: | CHRISTOPHE LECLERCQ MD PhD SERGE CAZEAU MD † DAVID LELLOUCHE MD ‡ FABIEN FOSSATI MD § FRÉDERIC ANSELME MD ¶ JEAN-MARC DAVY MD # NICOLAS SADOUL MD DIDIER KLUG MD †† LUCA MOLLO MD ‡‡ JEAN-CLAUDE DAUBERT MD FESC §§ |
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Institution: | From the Centre Cardio-Pneumologique, CHU, Rennes, France;, InParys, Saint-Cloud, France;;Hôpital Henri Mondor, Créteil, France;;Clinique du Bois, Lille, France;;Hôpital Charles Nicolle, Rouen, France;;CHU Montpellier, France;;Hôpital Brabois, Vandoeuvre lès Nancy, France;;CHU Lille, Lille, France;;ELA medical, Le Plessis Robinson, France;;Centre Cardio-Pneumologique, CHU, Rennes, France |
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Abstract: | Background: Biventricular (BiV) stimulation lowers morbidity and mortality in patients with drug-refractory congestive heart failure (CHF), depressed left ventricular (LV) function, and ventricular dyssynchrony in absence of indication for permanent cardiac pacing. This pilot, single-blind, randomized, cross-over study examined the safety and efficacy of upgrading conventional pacing systems to BiV stimulation in patients with advanced CHF . Methods: We included 56 patients in New York Heart Association (NYHA) functional classes III or IV despite optimal drug treatment and ventricular dyssynchrony (interventriclar delay >40 ms or LV preejection delay >140 ms) in need of pacemaker replacement. We compared the patients' functional status, arrhythmias, and standard echocardiographic measurements during 3 months of conventional, single right ventricular (RV) versus 3 months of BiV stimulation . Results: There were 44 patients in the cross-over phase. QRS duration was shortened by 23% and LV preejection delay by 16% with BiV stimulation. NYHA functional class, 6-minute hall walk and quality of life score were significantly improved with BiV stimulation compared with single RV pacing by 18%, 29%, and 19%, respectively. No significant difference was observed in the ventricular arrhythmia burden or LV reverse remodeling between the 2 periods . Conclusions: This pilot study showed that upgrading from RV pacing to BiV pacing significantly improves symptoms and exercise tolerance in chronically paced patients with advanced CHF and mechanical dyssynchrony . |
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Keywords: | heart failure ventricular dyssynchrony biventricular stimulation cardiac resynchronization therapy cardiac pacing |
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