莫诺苷的大鼠组织分布

目的研究莫诺苷在大鼠组织的分布特征。方法24只雄性sD大鼠随机分为4组，单剂量（30mg／kg）莫诺苷灌胃给药，分别于给药后5，45，120和360min股动脉放血处死动物，解剖取组织。采用高效液相色谱一串联质谱联用法测定莫诺苷浓度。结果大鼠给药5min即在小肠、胃、脾脏、肝脏和心脏达最高值，120min在脂肪组织中达最高值，其余组织均在45min达到最高值，360min后各组织的药物浓度均降至较低水平。结论莫诺苷在大鼠体内的吸收和分布较快，药物入血后在体内各组织分布较为广泛，在组织中的消除亦较快，结果提示药物没有组织蓄积趋势。

Tissue distribution of morroniside in rats

Objective To investigate the tissue distribution of morroniside in rats. Methods Twenty-four male SD rats were randomly divided into 4 groups. The samples of plasma and tissues were collected at 5,45, 120 and 360 min after oral administration of morroniside （30 mg/kg）. LC-MS/MS method was established to determine morroniside in the tissues of rats. Results Morroniside was orally administered in rats and the concentration of the drug reached the peak in the intestine ,stomach, spleen, liver and heart after 5 min and in fat after 120 min and in other tissues after 45 min, respectively. The concentration of morroniside in the tissues decreased to a very low level after 360 min. Conclusion Morroniside can be quickly absorbed, distributed and eliminated after oral administration in rats and no concentration accumulation is ohserved in the tissues.