Effects of verapamil and sodium cromoglycate on bronchoconstriction induced by isocapnic hyperventilation |
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| Authors: | P. RAFFERTY R. J. FERGUSSON P. M. TWEEDDALE B. A. BIGGS I. W. B. GRANT |
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| Affiliation: | Respiratory Unit and Lothian Area Respiratory Function Service, Northern General Hospital, Edinburgh, U.K. |
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| Abstract: | Twenty-four patients who were known to develop bronchoconstriction in response to isocapnic hyperventilation (IH) took part in a double-blind, placebo-controlled trial to assess the effects of verapamil (5 mg) and sodium cromoglycate (SCG) 20 mg in the prevention of IH-induced bronchoconstriction. Both drug and placebo were inhaled in dry powder form and responses were assessed by serial measurements of forced expiratory volume in 1 sec (FEV1). Sodium cromoglycate was shown to offer significant protection whereas verapamil powder provoked bronchoconstriction in over 40% of patients and these patients appeared to be those with more marked degrees of bronchial reactivity. |
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