| 步长脑心通对血管性痴呆大鼠血管内皮细胞生长因子作用的影响 |
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| 引用本文： | 魏瑞,何明大,刘石梅,黎红,王哲.步长脑心通对血管性痴呆大鼠血管内皮细胞生长因子作用的影响[J].脑与神经疾病杂志,2006,14(2):108-110. |
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| 作者姓名： | 魏瑞 何明大 刘石梅 黎红 王哲 |
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| 作者单位： | 1. 410008,长沙,中南大学湘雅医院肿瘤科
2. 中南大学湘雅二医院中医科 |
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| 摘 要： | 目的:观察步长脑心通对VD模型海马区血管内皮细胞生长因子(VEGF)的影响。方法:将50只大鼠随机分为正常组、假手术组、模型组、西药(喜德镇)组及步长脑心通组,建立实验动物模型。分别于制模后、30天后应用免疫组化法分析大鼠海马部位VEGF分布情况。结果:步长脑心通组大鼠海马组织内VEGF明显增加。结论:步长脑心通能明显增强VD模型大鼠海马组织VEGF表达,从而减轻VD模型大鼠的缺血性损伤。
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| 关 键 词： | 血管性痴呆 步长脑心通 血管内皮细胞生长因子 |
| 文章编号： | 1006-351X（2006）02-0108-03 |
| 收稿时间： | 2005-12-07 |
| 修稿时间： | 2005年12月7日 |
The effect of Buchang Naoxintong on vascular endothelial growth factor of vascular dementia |
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| WEI Rui, HE Mbzg-da, LIU Shi-mei ,el al.The effect of Buchang Naoxintong on vascular endothelial growth factor of vascular dementia[J].Journal of Brain and Nervous Diseases,2006,14(2):108-110. |
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| Authors: | WEI Rui HE Mbzg-da LIU Shi-mei el al |
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| Institution: | Department of Oncology, Xingya Hospital,Central South University, Changsha,410008 |
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| Abstract: | Objective:This study explored the mechanism of the Buchang Naoxintong (NXT) on the vascular dementia (VD) model rats ,and vascular endothelial growth factor in Hippocampus in VD Model Rats.Methods:Fifty rats were divided into a normal group ,sham-operation group,a model group,a western medicine group and a NXT group. VEGF expression in hippocampal structure of rat brain by using the methods of immunohistochemistry were measured after making model, behind thirty days to drug. Results: The content ofVEGF hippocampal structure of rat brain of the NXT group comparing with the model group increased significantly .Conclusions: The NXT can enhance the content of VEGF hippocampal structure of model rat brain;thus decrease the vascular injury of VD model rats. |
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| Keywords: | Vascular dementia Buehang Naoxintong vascular endothelial growth factor |
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