| 眼内铜异物所致脂质过氧化反应与视网膜损伤的关系 |
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| 引用本文： | 彭秀军 于纯智. 眼内铜异物所致脂质过氧化反应与视网膜损伤的关系[J]. 医学争鸣, 1990, 11(1): 18-21 |
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| 作者姓名： | 彭秀军 于纯智 |
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| 作者单位： | 西京医院眼科(彭秀军，于纯智)，第四军医大学化学教研室(莫简，孙淑芬)，第四军医大学化学教研室(王多宁) |
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| 摘 要： |
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| 关 键 词： | 眼异物 铜 视网膜损伤 脂质过氧化 |
Relationship between Copper-induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies |
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| PENG Xiu-Jun,YU Chun-Zhi,MO Jian,SUN Shu-Fen and WANG Duc-Ning. Relationship between Copper-induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies[J]. Negative, 1990, 11(1): 18-21 |
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| Authors: | PENG Xiu-Jun YU Chun-Zhi MO Jian SUN Shu-Fen WANG Duc-Ning |
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| Affiliation: | PENG Xiu-Jun,YU Chun-Zhi,MO Jian,SUN Shu-Fen and WANG Duc-Ning Department of Ophthalmology,Xijing Hospital,'Department of Chemistry |
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| Abstract: | At different times, malohdialdehydes (MDA) in the retinas and trace element copper in the aqueous and the vitreous were assessed; the changes of electroreti-inography (ERG) and pathology were observed after copper foreign bodies were placed nto vitreous of the rabbits. One day after the placement, the level of MDA increase by about three times in the retinas of the experimental eyes than in the control eyes (P<0.01) and ERG dropped rapidly following increase of copper ions in the vitreous. The increases of concentration of copper ions in the vitreous and MDA in the retinas are closely correlated (P<0.01). At the early stage, the electron micrograph of experimental eyes showed damage of retinal membrane structure rich in oxygen and inner segments. The results indicate that copper-induced lipid peroxidation is an important cause of retinal damage. |
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| Keywords: | eye foreign bodies copper eye injuries lipid peroxides electroretino-graphy |
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