| Abstract: | The effect of parenteral injections of insulin and its polypeptide A and B chains on the rate of protein metabolism in various organs of rats was investigated. Insulin was shown to accelerate the incorporation of [1-14C]glycine into proteins of the liver, kidneys, pancreas, spleen, skeletal muscle, and thyroid, thymus, and adrenal glands but to have no action on this process in heart muscle and the diaphragm. The A and B chains of insulin also activate protein synthesis in several organs. However, despite some specificity of their effect, the spectrum of their action is narrower than that of insulin.A. V. Vishnevskii Institute of Surgery, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR M. I. Kuzin). Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 4, pp. 419–421, April, 1978. |
