Morphofunctional characteristic of mast cells in BALB/c and C57Bl/6 mice during cold exposure |
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Authors: | Email author" target="_blank">G?V?TrunovaEmail author |
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Institution: | (1) Laboratory for Immunomorphology of Inflammation, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | Mast cells of the mesentery and subcutaneous tissue in BALB/c and C57Bl/6 mice were studied after single and repeated cold
exposure (−20°C, 3 min). Immediate adaptive reactions of mast cells in BALB/c and C57Bl/6 mice did not differ after single
cold exposure and were manifested in increased degranulation. Repeated cold exposure of BALB/c mice was followed by an adaptive
reaction, which included an increase in the count of mast cells in subcutaneous tissue and normalization of the degranulation
index. In C57Bl/6 mice the count of mast cells in subcutaneous tissue decreased, while the degranulation index remained high.
These changes reflect the disadaptive response of mast cells to repeated cold exposure.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 8, pp. 207–209, August, 2004 |
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Keywords: | cold exposure adaptation mast cells BALB/c and C57Bl/6 mice |
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