ＫＩＦ４Ａ在非小细胞肺癌中的表达及其与预后的相关性

目的　研究ＫＩＦ４Ａ蛋白在非小细胞肺癌（ＮＳＣＬＣ）组织中的表达及其与预后的相关性。方法　选取术后经病理证实的１１５例ＮＳＣＬＣ和１９例肺良性病变（５例肺结核、４例支气管扩张、６例肺大疱、４例炎性假瘤）的标本，运用免疫组化ＥｎＶｉｓｉｏｎ法检测ＫＩＦ４Ａ蛋白的表达，采用χ２检验分析ＫＩＦ４Ａ蛋白在ＮＳＣＬＣ组织和良性组织中的表达差异及ＮＳＣＬＣ中ＫＩＦ４Ａ蛋白表达与临床病理特征的相关性。采用Ｋａｐｌａｎ-Ｍｅｉｅｒ生存分析和Ｃｏｘ回归法分析ＫＩＦ４Ａ蛋白在ＮＳＣＬＣ组织中表达和预后的关系。结果　ＫＩＦ４Ａ在ＮＳＣＬＣ组织中阳性表达率为６０％，显著高于对照组的３１.６％，与Ｔ分期、淋巴结转移明显相关。生存分析提示，ＫＩＦ４Ａ阳性表达的ＮＳＣＬＣ患者预后较差（Ｐ＝０.００３）；Ｃｏｘ回归分析结果表明，ＫＩＦ４Ａ蛋白也是影响ＮＳＣＬＣ预后的独立危险因素（相对危险度１.９４４，Ｐ＝０.０３２）。结论　ＫＩＦ４Ａ蛋白在ＮＳＣＬＣ组织中的阳性表达率高于肺良性病变组织；ＫＩＦ４Ａ蛋白的高表达与ＮＳＣＬＣ患者预后相关，可以作为判断预后的参考指标。

The KIF4A expression and prognostic significance in non-small cell lung cancer

Objective To study the correlation between overexpression of KIF4A protein and clinicopathologic features and survival in non-small cell lung cancer（NSCLC）.Methods Immunohistochemical staining of Envision was applied to investigate the expression of KIF4A protein in specimens of 115 NSCLC and 19 benign pulmonary diseases.Correlation between the protein KIF4A in specimens of 115 NSCLC and clinicopathologic features were analyzed with χ2 test,and the correlation between the protein KIF4A expression and the overall survival were analyzed with Kaplan-Meier survival curve and Cox regression.Results The positive rate of KIF4A protein in specimens of NSCLC was 60%,which was significantly higher than 31.6%of the control.KIF4A expression was correlated with T-stage and N-Stage.Kaplan-Meire survival analysis and Log-rank test suggested that patients with KIF4A protein overexpression had poor prognosis（P=0.003）,and Cox regression suggested KIF4A protein expression was an independent prognostic factor of NSCLC.Conclusion The expression of KIF4A increases in specimens of NSCLC.Overexpression of KIF4A protein in NSCLC is correlated with prognosis and can serve as an independent prognostic factor of NSCLC.