| 丹酚酸B联合高氧液对兔肢体再灌注损伤保护作用 |
| |
| 引用本文： | 罗汉文,陈志维,李逸群,涂泽松.丹酚酸B联合高氧液对兔肢体再灌注损伤保护作用[J].中国矫形外科杂志,2010,18(6):507-509. |
| |
| 作者姓名： | 罗汉文 陈志维 李逸群 涂泽松 |
| |
| 作者单位： | 广东省佛山市中医院骨科,佛山,528000 |
| |
| 基金项目： | 佛山市科技攻关项目(编号:200708065) |
| |
| 摘 要： | 目的]探讨高氧液和丹酚酸B对兔肢体再灌注损伤的保护作用.方法]选用健康新西兰家兔24只,随机分为4组,在缺血前从耳缘静脉推注等虽的生理盐水(A组)、高氧液(B组)、丹酚酸B(C组)或高氧液加丹酚酸B(D组),夹阻股动静脉,建立肢体缺血再灌注损伤模型,在缺血前和再灌注4 h抽血检测丙二醛(MDA)和超氧化物岐化酶(SOD),取腓肠肌作病理检测.结果]再灌注损伤后血清丙二醛浓度较前明显升高,丹酚酸B组、高氧液组以及丹酚酸B联合高氧液组的MDA升高均受到抑制(P<0.01),以丹酚酸B联合高氧液组最为明显;血清超氧化物岐化酶活性较前明显降低,丹酚酸B组、高氧液组以及丹酚酸B联合高氧液组的SOD降低均受到抑制(P<0.01),以丹酚酸B联合高氧液组最为显著.骨骼肌HE染色见丹酚酸B联合高氧液组骨骼肌损伤程度最轻.结论]丹酚酸B联合高氧液和对兔肢体缺血再灌注损伤具有一定的保护作用,且两者有协同作用.
|
| 关 键 词： | 高氧液 丹酚酸B 再灌注损伤 |
Effect of salvianoli acid B and hyperoxic solution on experimental ischemia reperfusion injury of extremities |
| |
| LUO Han-wen,CHEN Zhi-wei,LI Yi-qun,et al..Effect of salvianoli acid B and hyperoxic solution on experimental ischemia reperfusion injury of extremities[J].The Orthopedic Journal of China,2010,18(6):507-509. |
| |
| Authors: | LUO Han-wen CHEN Zhi-wei LI Yi-qun |
| |
| Institution: | LUO Han-wen,CHEN Zhi-wei,LI Yi-qun,et al.Orthopedic Department,Traditional Chinese Medicine Hospital,Foshan 528000,China |
| |
| Abstract: | Objective]To investigate the effect of salvianoli acid B and hyperoxic solution on experimental ischemia reperfusion injury of extremities.Method]Twenty-four healthy New Zealand rabbits were divided into 4 groups randomly.Equivalent 0.9%Nacl(group A),hyperoxic solution(group B),salvianoli acid B(group C),salvianoli acid B and hyperoxic solution(group D) were injected through ear edge vein before ischemia.The femoral artery and vein were blocked and the model of ischemia reperfusion injury of extremities w... |
| |
| Keywords: | hyperoxic solution salvianoli acid B ischemia reperfusion injury |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
