Epidemiological Features of Aplastic Anemia in Indian Children |
| |
Authors: | Vineeta Gupta Raghvendra Pratap Akash Kumar Isha Saini Jyoti Shukla |
| |
Institution: | 1. Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India 2. Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
|
| |
Abstract: | Objectives To study the socio-demographic profile and clinico-hematological features of aplastic anemia in children presenting at a single institution over 5 y. Methods Patients below the age of 15 y presenting with features of aplastic anemia were included in the study. Epidemiology, clinico-hematological features and treatment received were recorded in all the cases. Serology for hepatitis A, B, C, E, EBV, parvovirus and HIV was carried out. Cytogenetic studies were available in approximately half of the patients. Results One hundred eighty five patients were diagnosed with aplastic anemia. Ten patients with inherited bone marrow failure syndrome (IBMFS) were excluded. Median age was 8 y (range 4–14 y) with a male to female ratio of 2.4:1. Pallor (100 %) followed by bleeding manifestations (83.8 %) and fever (73.5 %) were most common presenting symptoms. One hundred twenty patients (70 %) were classified as severe, 36 (21 %) very severe and 17 (9 %) non-severe aplastic anemia. Viral markers for parvovirus, Epstein barr virus and hepatitis were positive in 25.8 %, 20 % and 6.7 % patients respectively. Six patients had history of varicella infection in recent past (within 6 mo). Very few patients (30) could afford immunosuppressive therapy (IST) and had suboptimal response (29.7 %). Conclusions Majority of patients had idiopathic aplastic anemia. Very severe aplastic anemia and severe aplastic anemia were frequent. Few patients received IST and had suboptimal response. There is need to establish a national registry for aplastic anemia. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|