青蒿琥酯片预防疟疾效果观察

为了观察青蒿琥酯片预防疟疾的效果,1991～1992年选择疟疾高发区——三亚市高峰乡福万水库和电站作为试验压,以户为单位将试验区人口分为青蒿琥酯片试验组和安慰剂对照组,进行对照观察。1992年以1991年分组为基础,两组互相对换服药,增加人员以户为原则分别编入两组内。1991年试验组与对照组人数分别为77人与56人,1992年分别为75人与79人。试验组每周一次口服青蒿琥酯片100mg,1991年连服13周,1992年连服16周。结果:1991年试验组无发病,对照组发病率为8.93％(P<0.01);1992年试验组发病率为4.0％,对照组为13.92％(P<0.05);两年合计发病率试验组为1.97％,对照组为11.85％(P<0.01)。观察结果提示,虽然青蒿琥酯是一个速效而半衰期甚短的抗疟药,但是每周口服100mg对于疟疾的预防有一定的作用,且未发现任何副反应。对于短期进入疟区作业的人群,采用该方案是可行的。

The Preventive Effect of Artesunate Tablet on Malaria

Aiming at observing the preventive effect of artesunate tablet on malaria, 100 mg of artesunate tablet were taken orally once a week for selected population in malaria endemic area, with placebo as control. After 13 weeks no malaria parasite was observed in artesunate group and the positve rate of malaria parasite in blood smears in control group was 8.93% (P<0.01)in 1991. After 16 weeks the positive rate of malaria parasite was 4.0% and 13.92% in artesunate and control groups (P<0.05) in 1992. The accumulative positive rate of malaria parasite in two years was 1.97% and 11.85% respectively (P<0.01). It is indicated that oral administration of artesunate tablet at a dosage of 100 mg once a week for adults exerts a certain preventive effect on malarla, especially those who immigrate into the endemic area for a short time. No side effect was observed during the period of drug administration.