Fcgamma receptor regulation of Citrobacter rodentium infection |
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Authors: | Masuda Atsuhiro Yoshida Masaru Shiomi Hideyuki Ikezawa Satoshi Takagawa Tetsuya Tanaka Hiroshi Chinzei Ryo Ishida Tsukasa Morita Yoshinori Kutsumi Hiromu Inokuchi Hideto Wang Shuo Kobayashi Kanna Mizuno Shigeto Nakamura Akira Takai Toshiyuki Blumberg Richard S Azuma Takeshi |
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Institution: | Department of Gastroenterology, Kobe University School of Medicine, 7-5-1, Chu-o-ku, Kusunoki-Cho, Kobe, Hyogo 650-0017, Japan. |
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Abstract: | Citrobacter rodentium, a murine model pathogen for enteropathogenic Escherichia coli, colonizes the colon utilizing attaching and effacing lesions to adhere specifically to the surfaces of intestinal epithelial cells and cause mucosal inflammation. CD4+ T cells, B cells, and immunoglobulin G (IgG), but not secretory IgA or IgM, play a critical role in eradicating this pathogen. Consistent with the importance of IgG in C. rodentium eradication, IgG transport by the neonatal Fc receptor for IgG within the intestinal epithelium also has a critical role in the regulation of C. rodentium infection. It remains to be determined, however, whether Fcgamma receptors (FcgammaRs), the receptors for the Fc portion of IgG, regulate this bacterial infection within mucosal tissues. Therefore, we investigated the roles of FcgammaRs during C. rodentium infection. Fc receptor common gamma chain (FcRgamma)-deficient mice were more susceptible to C. rodentium-induced colitis. This occurred through decreased efficiency of FcR-mediated endocytosis and maturation of dendritic cells and consequently T-cell activation of antigen-specific T cells. Moreover, in the absence of FcgammaRs, phagocytosis by macrophages was significantly diminished. Therefore, activating FcgammaRs play an important role in defending against C. rodentium infection, indicating that the critical role played by IgG in this infection is not mediated by IgG alone but is dependent upon this class of receptors. |
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