Neuropsychological functions and metabolic aspects in subclinical hypothyroidism: The effects of l-thyroxine |
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| Authors: | Marina Baldini Alessandro Colasanti Alessandra Orsatti Lorena Airaghi Massimo C. Mauri Maria Domenica Cappellini |
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| Affiliation: | 1. U.O. Medicina Interna 1 A, Padiglione Granelli, IRCCS Fondazione Policlinico, MA., R.E., via Francesco Sforza 35, 20122, Milan, Italy;2. U.O. Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, IRCCS Fondazione Policlinico, MA., R.E., via Francesco Sforza 35, 20122, Milan, Italy;3. Internal Medicine Department, Università degli Studi di Milano, Italy;4. U.O. Medicina Interna 1 B, Padiglione Granelli, IRCCS Fondazione Policlinico, MA., R.E., via Francesco Sforza 35, 20122, Milan, Italy |
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| Abstract: | Thyroid hypofunction is a slowly progressing graded phenomenon [Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 1995;43(1):55–68]; subclinical forms (SCH) often represent a laboratory diagnosis in apparently asymptomatic patients. In the absence of adequate parameters for thyroid hormone action in tissues, the level of TSH increase corresponding to negative effects remains unsettled. |
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| Keywords: | EMG, euthyroid multinodular goiter FT3, free triiodothyronine FT4, free thyroxine GLM, General Linear Model HDL, high density lipoprotein HOMA, Homeostasis Model Assessment for Insulin Resistance HRSD, Hamilton Rating Scale for Depression HRSA, Hamilton Rating Scale for Anxiety LDL, low density lipoprotein LT4, levothyroxine RT, reaction times SCH, subclinical hypothyroidism SF-36, Short Form 36 TSH, thyroid stimulating hormone WMS, Wechsler Memory Scale |
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