Dopamine receptor subtypes contribution to Homer1a induction: Insights into antipsychotic molecular action |
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| Authors: | Felice Iasevoli Carmine TomasettiAlberto Ambesi-Impiombato Giovanni MuscettolaAndrea de Bartolomeis |
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| Affiliation: | Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neurosciences, University School of Medicine “Federico II”, Via Pansini 5, 80131 Naples, Italy |
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| Abstract: | The inducible gene Homer1a has been considered a candidate gene for schizophrenia. Drugs efficacious in schizophrenia and acting as dopamine receptor antagonists induce Homer1a expression, although the specific role of the different dopamine receptors in its induction is not completely known. |
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| Keywords: | ACC, anterior cingulated cortex ANOVA, analysis of variance CAcc, core of the nucleus accumbens DG, dentate gyrus DL, dorsolateral putamen DM, dorsomedial putamen IC, infralimbic cortex IEG, immediate-early gene L-741,626, 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole L-745,870, 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine MAC, medial agranular cortex MC, motor cortex mGluRs, metabotropic glutamate receptors NMDA, N-methyl-d-aspartate OD, optical density PSD, postsynaptic density ROI, region of interest SAcc, shell of the nucleus accumbens SCH-23390, R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride SS, somatosensory cortex U-99194, 5,6-dimethoxy-2-(dipropylamino)indan hydrochloride VL, ventrolateral putamen VM, ventromedial putamen |
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