The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test |
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Authors: | Bernadeta Szewczyk Ewa Poleszak Piotr Wlaź Andrzej Wróbel Eliza Blicharska Agnieszka Cichy Małgorzata Dybała Agata Siwek Lucyna Pomierny-Chamioło Anna Piotrowska Piotr Brański Andrzej Pilc Gabriel Nowak |
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Institution: | 1. Laboratory of Trace Elements Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Sm?tna 12, PL 31-343 Kraków, Poland;2. Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Sm?tna 12, PL 31-343 Kraków, Poland;3. Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Staszica 4, PL 20-081 Lublin, Poland;4. Department of Animal Physiology, Institute of Biology, Maria Curie-Sk?odowska University, Akademicka 19, PL 20-033 Lublin, Poland;5. Second Department of Gynecology, Medical University of Lublin, Jaczewskiego 8, PL 20-090 Lublin, Poland;6. Department of Analytical Chemistry, Medical University of Lublin, Staszica 6, PL 20-081 Lublin, Poland;g Laboratory of Pharmacobiology, Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland;h Institute of Public Health, Collegium Medicum, Jagiellonian University, Grzegórzecka 20, PL 31-531 Krakow, Poland |
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Abstract: | Recent preclinical data indicated the antidepressant-like activity of zinc in different tests and models of depression. The present study investigates the involvement of the serotonergic system in zinc activity in the forced swim test (FST) in mice and rats. The combined treatment of sub-effective doses of zinc (hydroaspartate, 2.5 mg Zn/kg) and citalopram (15 mg/kg), fluoxetine (5 mg/kg) but not with reboxetine (2.5 mg/kg) significantly reduces the immobility time in the FST in mice. These treatments had no influence on the spontaneous locomotor activity. Moreover, while the antidepressant-like effect of zinc (5 mg/kg) in the FST was significantly blocked by pretreatment with inhibitor of serotonin synthesis, p-chlorophenylalanine (pCPA, 3 × 200 mg/kg), 5HT-2A/C receptor antagonist, ritanserin (4 mg/kg) or 5HT-1A receptor antagonist, WAY 1006335 (0.1 mg/kg), the zinc-induced reduction in the locomotor activity was not affected by these serotonin modulator agents. These results indicate the specific involvement of the serotonergic system in antidepressant but not the motion behavior of zinc in mice. Also, an increase in the swimming but not climbing parameter of the rat FST observed following zinc administration (2.5 and 5 mg Zn/kg) indicates the serotonin pathway participation. This present data indicates that the antidepressant-like activity of zinc observed in the FST involves interaction with the serotonergic system. |
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Keywords: | i p intraperitoneally CIT citalopram FX fluoxetine RB reboxetine RIT ritanserin WAY WAY 1006335 pCPA p-chlorophenylalanine NMDA N-methyl-d-aspartate BDNF brain-derived neurotrophic factor FST forced swim test |
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