Therapeutic efficacy of Picroliv in chronic cadmium toxicity

Cadmium (Cd), an industrial and environmental pollutant, is toxic to several tissues, most notably causing hepatotoxicity on acute administration and nephrotoxicity following chronic exposure. The therapeutic efficacy of Picroliv – a standardized fraction of Picrorhiza kurroa, was investigated in male rats treated with Cd as CdCl₂ (0.5 mg/kg, sc) 5 days/week for 24 weeks and Picroliv at two doses (6 and 12 mg/kg, p.o.) was given during the last 4 weeks.