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Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma
Authors:Won-Kyo Jung  Inhak Choi  Sangtaek Oh  Sae-Gwang Park  Su-Kil Seo  Soo-Woong Lee  Dae-Sung Lee  Soo-Jin Heo  You-Jin Jeon  Jae-Young Je  Chang-Bum Ahn  Jin Soo Kim  Kwang Soo Oh  Young-Mog Kim  Chisook Moon  Il-Whan Choi
Affiliation:1. Department of Marine Life Science and Marine Life Research Center, Chosun University, Gwangju 501-759, Republic of Korea;2. Department of Microbiology and Bio-Marker Research Center for Personalized Therapy, College of Medicine, Inje University, Busan 614-735, Republic of Korea;3. PharmacoGenomics Research Center, Inje University, Busan 614-735, Republic of Korea;4. Department of Microbiology, Pukyong National University, Busan 608-737, Republic of Korea;5. Faculty of Applied MarineScience, Cheju National University, Jeju 690-756, Republic of Korea;6. Department of Food Science and Aqualife Medicine, Chonnam National University, Yeosu 550-749, Republic of Korea;g Division of Marine Life Science, Gyeongsang National University, Tongyong 650-160, Republic of Korea;h Faculty of Food Science and Biotechnology, Pukyong National University, Busan 608-737, Republic of Korea;i Department of Internal Medicine, Busan-Paik Hospital, Inje University, Busan 614-735, Republic of Korea
Abstract:The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing; the development of airway hyperresponsiveness; the detection of TNF-α and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L. undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases.
Keywords:Red alga   Laurencia undulata   Asthma   Cytokines   Airway hyperresponsiveness
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