Functional correlates for 5-HT1A receptors in maternally deprived rats displaying anxiety and depression-like behaviors |
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Authors: | Laura Lambá s-Señ as,Ouissame Mnie-Filali,Vé ronique Certin,Cé line Faure,Laetitia Lemoine,Luc Zimmer,Nasser Haddjeri |
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Affiliation: | 1. Université de Lyon, F-69008, Lyon, France;2. Université Lyon 1, Faculté de Pharmacie, Laboratoire de Neuropharmacologie, Lyon, F-69008, France;3. CNRS, FRE 3006, F-69373, Lyon Cedex 08, France;4. CERMEP—Imagerie du vivant, Département ANIMAGE, F-69677, Bron, Lyon, France |
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Abstract: | Maternal separation is known to induce long-term changes in neuroendocrine and emotional responsiveness to stress in a large variety of models. We examined an animal model of early deprivation in Sprague–Dawley rats consisting of separating litters from their mothers and littermates 3 h daily during postnatal days 2 to 15. In adulthood, maternally deprived rats in comparison with non-deprived controls exhibited an increase in anxiety and depression-related behaviors in the open-field and forced swim tests. Because serotonin (5-HT) 5-HT1A receptors seem to play an important role in the pathophysiology of major depression and in the mechanism of action of antidepressants, we investigated if 5-HT1A receptor function is altered in deprived rats. Although the hypothermic response to the 5-HT1A receptor agonist 8-OH-DPAT was increased in adult deprived rats compared to non-deprived control group, no differences between groups were found in the effect of the systemic 8-OH-DPAT administration on serotoninergic cell firing in dorsal raphe nucleus and in the 5-HT release at the ventral hippocampus levels. These results suggest that 5-HT1A receptors are not substantially affected in adult Sprague–Dawley rats that were subjected to a maternal deprivation 3 h daily during the neonatal period. |
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Keywords: | 5-HT, serotonin 8-OH-DPAT, 8-hydroxy-2-(di-n-propylamino)tetralin DEP, deprived DR, dorsal raphe HPA, hypothalamo-pituitary-adrenal HPLC/EC, high performance liquid chromatography combined with electrochemical detection NDEP, non-deprived |
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