Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population |
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| Authors: | Tomo Okochi Taro Kishi Masashi Ikeda Tsuyoshi Kitajima Yoko Kinoshita Kunihiro Kawashima Takenori Okumura Tomoko Tsunoka Toshiya Inada Mitsuhiko Yamada Naohisa Uchimura Masaomi Iyo Ichiro Sora Norio Ozaki Hiroshi Ujike Nakao Iwata |
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| Affiliation: | 1. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan;2. Department of Psychiatry, Teikyo University Ichihara Hospital, Ichihara, Japan;3. Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan;4. Department of Neuropsychiatry, Kurume University Graduate School of Medicine, Kurume, Japan;5. Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan;6. Department of Psychobiology Tohoku University Graduate School of Medicine, Sendai, Japan;g Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;h Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan;i Japanese Genetics Initiative for Drug Abuse (JGIDA), Japan |
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| Abstract: | The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and METH-induced psychosis in a Japanese population (184 subjects with METH-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population. |
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| Keywords: | NRG1, The neuregulin 1 gene METH, methamphetamine NMDA, N-methyl D-aspartate GABA, gamma-aminobutyric acid Ach, acetylcholine JGIDA, Japanese Genetics Initiative for Drug Abuse HWE, Hardy&ndash Weinberg equilibrium SNP, Single Nucleotide Polymorphism |
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