Inverse Dose Effect of Pretest Dietary Lactose Intake on Breath Hydrogen Results and Symptoms in Lactase Nonpersistent Subjects |
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Authors: | Andrew Szilagyi MD Paula Malolepszy BSc Samara Yesovitch BA Usha Nathwani PDt Christina Vinokuroff PDt Albert Cohen MD Xiaoqing Xue Msc |
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Institution: | (1) Division of Gastroenterology, Department of Medicine, Sir Mortimer B. Davis—Jewish General Hospital, McGill University, Montreal, Quebec, Canada;(2) Department of Dietetics, Sir Mortimer B. Davis—Jewish General Hospital, McGill University, Montreal, Quebec, Canada;(3) Department of Emergency Medicine, Sir Mortimer B. Davis—Jewish General Hospital, McGill University, Montreal, Quebec, Canada;(4) Division of Gastroenterology, Department of Medicine, Sir Mortimer B. Davis—Jewish General Hospital, 3755 Cote Ste-Catherine, room G-327, Montreal, Quebec, Canada, H3T 1E2 |
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Abstract: | The aim of this study was to determine a relationship between pretest intake of lactose and outcome of lactose breath hydrogen
test. Patients presented at a testing laboratory participated in the study. A 3-hour breath hydrogen, 50-g lactose challenge
was carried out. Results were tabulated and patients completed a 3-day recall diet questionnaire. Daily lactose intake was
independently calculated and was associated with breath hydrogen and total symptom score. Statistical analysis used Spearman's
correlation, Mann-Whitney U-test and χ2 or Fisher exact test. Of 118 patients, 50% were lactose maldigesters. In these patients, measured breath hydrogen and symptom
scores were significantly higher in the lowest intake group (< 5 g/d) than in the highest intake group (> 20 g/d) (P < .05). In the presumed lactose digesters, 59% experienced some symptoms during testing for unclear reasons. Pretest dietary
intake of lactose inversely affects results of breath hydrogen. |
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Keywords: | dietary effects lactose breath hydrogen test |
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