| 组蛋白乙酰化/去乙酰化与肺部疾病 |
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| 引用本文： | 邹志,李万成.组蛋白乙酰化/去乙酰化与肺部疾病[J].医学综述,2007,13(23):1763-1765. |
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| 作者姓名： | 邹志 李万成 |
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| 作者单位： | 泸州医学院附属医院呼吸内科,四川,泸州,646000 |
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| 摘 要： | 组蛋白乙酰化修饰与基因的表达调控相关,参与了各种肺部疾病的病变过程。组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。二者之间的动态平衡在特定条件下被破坏,会导致基因转录的失调,引起基因表达的异常。
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| 关 键 词： | 肺疾病 组蛋白 组蛋白乙酰基转移酶 组蛋白去乙酰化酶 基因表达 |
| 文章编号： | 1006-2084(2007)23-1763-03 |
| 修稿时间： | 2007年3月24日 |
Acetylation/Deacetylation of Histone and Lung Diseases |
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| ZOU Zhi,LI Wan-cheng.Acetylation/Deacetylation of Histone and Lung Diseases[J].Medical Recapitulate,2007,13(23):1763-1765. |
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| Authors: | ZOU Zhi LI Wan-cheng |
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| Abstract: | The acetylation of histone is related to gene expression and regulation,which takes part in the pathological courses of all kinds of lung diseases.The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.If the dynamic equilibrium between them was destro yed under certain condition,it will result in disturbance of genetic trans cription as well as abnomal gene expression at last. |
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| Keywords: | Lung diseases Histone Histone acetyltransferase Histone deacetylase Gene expression |
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