氯丙咪嗪合并利培酮治疗强迫症的对照研究

目的探讨利培酮对于氯丙咪嗪治疗强迫症的增效作用。方法将70例强迫症随机分为2组,氯丙咪嗪同时合并利培酮和单独使用氯丙咪嗪治疗,治疗8周。采用强迫症量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评定疗效。结果合并利培酮组有31例完成试验,氯丙咪嗪组有32例完成试验。治疗8周后,两组Y-BOCS平均总分有明显下降,合并利培酮组优于氯丙咪嗪组,两组无显著性差异(P<0.05);HAMA、HAMD的评分均显著下降,两组无显著性差异(P>0.05)。结论合并利培酮对于氯丙咪嗪治疗强迫症有增效作用。

Comparative study of clomipramine with risperidone and clomipramine alone in the treatment of obsessive - compulsive disorder

Objective:To investigate the superior effectiveness of risperidone combining with clomipramine in the tretment of obsessive-compulsive disorder(OCD).Methods:31 patients with OCD were treated by risperidone combining with clomipramine and 32 patients were treated by clomipramine only for 8 weeks,The efficacy was measured with Yale-Brown obsessive compulsive scale(Y-BOCS),Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD).Results:After 8 weeks,there were significant differences between two groups in overall response showed by the reduction rate of Y-BOCS total scores ;whereas no snignificant differences in HAMA and HAMD total scores between them.Conclusion:It is suggested that risperidone combining clomipramine have a superior effectivenees in the treatment of OCD.