复配杀虫剂最佳增效配方的快速筛选及其计算机程序实现

目的采用国际通用的SAS统计分析平台编制计算机程序,实现复配杀虫剂最佳增效配方的快速筛选。方法以朱砂叶螨为试虫,对A、B2种药剂按一定比例复配后进行毒力测定及计算机程序演算,拟合质量分数反正弦变换值——共毒系数（CTC）的多项式数学模型,对模型曲线求导,计算最大CTC及最佳复配比例。结果多项式数学模型有统计学意义（F=20.76,P〈0.05）,总决定系数（R2）=0.9540;模型方程：CTC=-2.021499X2＋222.543940X-5951.467969;曲线求导,计算得最佳极值X=55.04,对应的最大CTC=173.42,最佳复配比例为2：1。结论建立的快速筛选方法及编制的程序计算结果经双重验证,证明准确、可靠,且简便、快捷。

Rapid screening for the optimal synergistic formula for pesticide formulations and its program realization

Objective A computer program was developed based on the internationally recognized statistics analysis system（SAS） to rapidly screen for the optimal synergistic formula for pesticide formulations.Methods Agents A and B were combined in a certain ratio and subject to the determination of toxicity against Tetranychus cinnabarinus and the computer program calculations for fitting the polynomial mathematical model of the co-toxicity coefficient（CTC）,the arcsine transformation of the mass fraction.The derivative of the model curve was calculated and the maximum CTC and the optimal formulation ratio were computed.Results The polynomial mathematical model was statistically significant（F=20.76,P0.05）,the total coefficient of determination（R2）=0.9540;the model equation was：CTC=-2.021 499X2＋222.543 940X-5951.467 969;the derivation of the curve revealed the best extreme value X=55.04,with the corresponding maximum CTC of 173.42 and the optimal formulation ratio of 2：1.Conclusion Upon dual verification using program calculations,the established screening method proved to be an accurate,reliable,rapid and user-friendly approach to screen for the optimal synergistic formula.