| 非小细胞肺癌NP方案化疗敏感性与DNA修复基因XRCC1多态性的关系 |
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| 引用本文： | 洪成雨,徐倩,岳峥,张晔,袁媛.非小细胞肺癌NP方案化疗敏感性与DNA修复基因XRCC1多态性的关系[J].癌症,2009,28(12):1291-1297. |
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| 作者姓名： | 洪成雨 徐倩 岳峥 张晔 袁媛 |
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| 作者单位： | 中国医科大学附属第一医院普通外科研究所暨肿瘤研究所辽宁省高校肿瘤病因与预防重点实验室;辽宁省肿瘤医院内四科; |
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| 摘 要： | 背景与目的:基因多态预测肿瘤化疗药物敏感性对肿瘤个体化治疗具有重要意义。本研究旨在探讨DNA修复基因XRCC1 codon194及399位点基因多态性与非小细胞肺癌长春瑞滨加顺铂(vinorelbine and cisplatin,NVB and DDP,NP)方案化疗敏感性的关系。方法:采用聚合酶链反应-限制性片段长度多态性技术检测164例非小细胞肺癌患者外周血DNAXRCC1194和399位点的多态性。选择NP方案化疗,化疗两周期后评价疗效,并分析化疗敏感性与基因多态性的关系。结果:携带XRCC1基因Codon194C/T+T/T基因型者化疗有效率(41.8%)是C/C基因型者(26.0%)的2.038倍(P=0.036,95%CI=1.044-3.976)。携带XRCC1基因Codon399G/G、A/G、A/A型的患者化疗有效率(37.1%,34.6%,14.3%)之间的差异无统计学意义(P>0.05)。应用分析软件SHEsis发现以
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| 关 键 词： | DNA修复基因 XRCC1 多态性 肺肿瘤 癌 非小细胞 NP方案 化疗敏感性 |
Correlation of the sensitivity of NP chemotherapy in non-small lung cancer with DNA repair gene XRCC1 polymorphism |
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| Cheng-Yu Hong, Qian Xu, Zheng Yue, Ye Zhang , Yuan Yuan .Cancer Control Laboratory of Cancer Institute , General Surgery Institute,The First Affiliated Hospital of China Medical University,The Key Laboratory of Cancer Control of Liaoning Province,Shenyang,Liaoning,P.R.China.Correlation of the sensitivity of NP chemotherapy in non-small lung cancer with DNA repair gene XRCC1 polymorphism[J].Chinese Journal of Cancer,2009,28(12):1291-1297. |
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| Authors: | Cheng-Yu Hong Qian Xu Zheng Yue Ye Zhang Yuan Yuan Cancer Control Laboratory of Cancer Institute General Surgery Institute The First Affiliated Hospital of China Medical University The Key Laboratory of Cancer Control of Liaoning Province Shenyang Liaoning PRChina |
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| Institution: | Cheng-Yu Hong,1,2 Qian Xu,1 Zheng Yue,1 Ye Zhang1 , Yuan Yuan1 1.Cancer Control Laboratory of Cancer Institute , General Surgery Institute,The First Affiliated Hospital of China Medical University,The Key Laboratory of Cancer Control of Liaoning Province,Shenyang,Liaoning,110001,P.R.China 2.Department 4th of Oncology,Tumor Hospital of Liaoning Province,110042,P.R.China |
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| Abstract: | Background and Objective:The gene polymorphism is used to predict the sensitivity of chemotherapy,which is significant for the individualized treatment of tumor.This study was to explore the correlation of codon 194 and codon 399 polymorphisms of DNA repair gene X-ray repair cross complementing(XRCC1)with the sensitivity of non-small cell lung cancer(NSCLC)to NP(vinorebine and cisplatin)chemotherapy.Methods:XRCC1 polymorphisms at codon 194 and codon 399 were detected in 164 patients with NSCLC using polymer... |
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| Keywords: | DNA repair gene X-ray repair cross complementing 1(XRCC1) polymorphism lung neoplasm non-small cell carcinoma NP chemotherapy chemotherapy sensitivity |
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