欣母沛治疗宫缩乏力性产后出血的疗效和安全性分析

目的探讨欣母沛治疗宫缩乏力性产后出血的临床疗效及安全性。方法选取2010年3月～2013年2月我院收治的66例宫缩乏力性产后出血患者,随机分为观察组和对照组各33例,对照组采用常规治疗措施,观察组在对照组常规治疗的基础上给予欣母沛治疗,观察并比较两组患者的临床疗效、治疗后出血量及不良反应的发生率。结果观察组总有效例数为32例,总有效率为96.97%,对照组总有效例数为25例,总有效率为75.76%,两组患者临床疗效比较差异有统计学意义（P〈0.05）;观察组产后2h及24h出血量分别为（223.1±47.5）mL和（298.4±58.1）mL,对照组产后2h及24h出血量分别为（345.3±55.5）mL及（457.2±71.2）mL,观察组均低于对照组,两组患者产后出血量比较差异有统计学意义（P〈0.05）;两组患者治疗过程中均无严重不良反应发生,对照组有1例患者出汗,1例患者出现面部潮红,1例患者出现恶心呕吐,不良反应的发生率为9.09%,观察组有1例患者出现恶心呕吐,不良反应的发生率为3.03%,两组患者不良反应发生率相比较差异有统计学意义（P〈0.05）。结论采用欣母沛治疗宫缩乏力性产后出血临床疗效好,不良反应的发生率低,值得在临床上予以推广。

Therapeutic efficacy and safety analysis of Hemabate in treating postpartum hemorrhage with uterine atony

Objective To evaluate the clinical efficacy and safety of hemabate in the treatment of uterine inertia postpartum hemorrhage. Methods 66 cases of patients with uterine inertia postpartum hemorrhage selected from March 2010 to February 2013 in our hospital were randomLy divided into observation group and control group, the control group had 33 patients with conventional treatment, 33 cases of the observation group had been given hemabate on the basis of conventional treatment same as the control group, the clinical effect, the amount of bleeding after treatment and the incidence of adverse reactions of the two groups were observed and compared. Results The total effective cases was to 32 cases, total effective rate was 96.97% in the control group, the total effective number of cases was 25 cases, total effective rate was 75.76%, the two groups had statistically significant differences in clinical efficacy（P〈0.05）; 2h and 24 h post-partum bleeding of observation group, respectively was（223.1±47.5） mL and（298.4±58.1） mL, 2h and 24 h postpartum bleeding of control group, respectively was（345.3±55.5） mL and（457.2±71.2） mL, observation group was lower than the control group, the difference of postpartum hemorrhage amount between the two groups was statistically significant（P〈0.05）; treatment processes of patients in both groups without serious adverse events, one patient with sweating, one case with facial flushing, one patient with nausea and vomiting in the control group, the occurrence rate of adverse reactions was 9.09%, one patients had nausea and vomiting in the observation group, the occurrence rate of adverse reactions was 3.03%,compared the incidence of adverse reactions in both groups that the difference was statistically significant（P〈0.05）. Conclusion It had good clinical efficacy and low incidence of adverse reactions in treating uterine inertia Postpartum Hemorrhage with hemabate, and it was worth to be promoted in clinic.