米非司酮治疗子宫肌瘤51例临床疗效分析

目的探讨米非司酮治疗子宫肌瘤51例的临床疗效。方法选择2011年4月～2013年4月确诊为子宫肌瘤的患者51例,给予口服米非司酮治疗。超声检测子宫及子宫肌瘤的大小,实验室检测血清激素水平,观察服药后的不良反应等。结果经过一段时间的治疗后肌瘤缩小明显（P〈0.05）;经过治疗后LH、E2、FSH、P指标明显下降有统计学意义（P〈0.05）,但是催乳素（PRL）下降不明显（P〉0.05）。本次临床观察51例患者中随访到49例患者,随访率为96.1%。其中30例患者在1个月内恢复月经,10例患者在2个月内恢复月经,还有4例患者在半年后恢复月经。随访的所有患者当中瘤体没有增大的有40例占81.6%,瘤体增大的有5例,经手术切除瘤体的有3例,还有1例患者行子宫全切术。结论米非司酮治疗子宫肌瘤效果好,不良反应少,有积极的临床价值。

The clinical curative effect analysis of mifepristone in treatment of 51 cases of patients with uterine fibroids

Objective To explore the clinical effect of mifepristone in treatment of 51 cases of patients with uterine fibroids. Methods A total of 51 cases of patients diagnosed with uterine fibroids from April 2011 to April 2013 in our hospital were selected and treated with mifepristone orally. The size of the uterus and uterine myoma were detected by ultrasound, and the serum hormone levels were tested in laboratory, and the adverse events during the medication was observed. Results After a period of treatmen, the sizes of uterine fibroids decreased obviously with statistically significant differences（P〈0.05）. The indicators of LH, E2, FSH were decreased obviously with statistically significant differences（P〈0.05）. But the decrease of PRL was not significant（P〈0.05）. A total of 49 cases in 51 patients were followed up during the clinical observation with the follow-up rate being 96.1%. 30 cases were returned to menses within one month, 10 cases were returned to menses within 2 months, 4 cases were returned to menses within half a year. The tumors of 40 patients were not larger（81.6%）, and the tumors of 5 patients were larger. There was 3 cases treated by removal surgery, and 1 case treated with total hysterectomy. Conclusion The clinical effect of mifepristone in the treatment of uterine fibroids is good with few adverse reactions and positive clinical value.