醒脑静注射液辅助治疗小儿热性惊厥的效果

目的观察醒脑静注射液辅助治疗小儿热性惊厥的效果。方法将60例热性惊厥患儿随机分为两组,各30例。对照组给予止惊、抗感染、退热、吸氧等常规对症支持治疗,治疗组在此基础上给予醒脑静注射液0.2～0.6mL/（kg·d）,1次/d。7d为1个疗程。观察指标包括：临床疗效、退热时间、住院时间、惊厥复发以及癫痫发生情况、不良反应发生情况。结果治疗组总有效率达93.3%,显著高于对照组（76.7%）,差异有统计学意义（P〈0.05）。治疗组退热时间（1.48±0.16）d、住院时间（2.48±0.56）d,均显著短于对照组（2.23±0.47）d、（4.97±1.34）d],差异均有统计学意义（P〈0.05）。随访1年后,治疗组惊厥复发次数（2.85±0.24）/次明显低于对照组（3.91±1.48）/次,差异有统计学意义（P〈0.05）,两组癫痫发生率比较差异无统计学意义（P〉0.05）。两组不良反应发生率比较差异无统计学意义（P〉0.05）。结论醒脑静注射液辅助治疗小儿热性惊厥能显著提高临床疗效,明显缩短退热及住院时间,减少惊厥复发次数,值得临床推广应用。

Effect of Xingnaojing injection in adjuvant therapy of children with febrile convulsion

Objective To observe the effect of Xingnaojing Injection in adjuvant therapy of children with febrile convulsion. Methods 60 cases of children with febrile convulsion were randomly divided into two groups,with 30 cases in each group.Control group was given conventional symptomatic and supportive treatment,such as anti-convulsion,antiinfection,abatement of fever,oxygen uptake,and so on,on basis of which,treatment group was given Xingnaojing Injection 0.2-0.6mL/（kg·d）,once a day.The course was 7 days.The observational indexes included：clinical effect;abatement time of fever,length of stay;recurrence of convulsion,epileptogenesis. Results The total effective rate of treatment group was 93.3%,which was higher than that of control group（76.7%）,the difference was statistically significant（P〈0.05）.The abatement time of fever（1.48±0.16）/d,length of stay（2.48±0.56）/d in the treatment group were all shorter than those of control group（2.23±0.47）d,（4.97±1.34） d,the differences were all statistically significant（P〈0.05）.After follow-up of 1 year, the times of recurrence of convulsion（2.85±0.24） times in the treatment group was lower than that of control group（3.91±1.48） times,the difference was statistically significant（P〈0.05）,the incidence of epilepsy in the two groups had no statistically significant difference（P〈0.05）.There were no statistically significant difference of the incidence of adverse reactions between the two groups（P〈0.05）. Conclusion Xingnaojing Injection in adjuvant therapy of children with febrile convulsion can improve clinical effect obviously,shorten abatement time of fever and length of stay,reduce the times of recurrence of convulsion,which is worthy of clinical promotion and application.